How the spike protein has led me to revise my understanding of the pandemic
This article is an "off-the-cuff" presentation of ideas. I'm not deeply committed to the ideas here, but I think it is good to air viewpoints sometimes which run contrary to one's normal opinions. This can sometimes aid in developing a way of falsifying one's pre-existing hypotheses.
I am starting to warm to the idea that SARS-CoV-2 is a product of "gain of function" research.
My thinking on this has shifted somewhat from the idea that the whole thing is a hoax.
The main reason for my evolving view on this is the recent information about the specific toxic effects of the "spike protein", which is found on the virus and which is produced by cells of people who've been vaccinated against the virus.
If we look at the known effects of the spike protein, we see a disease process which is unlike anything in our experience. Most people are unaffected and some have very mild flu-like symptoms. A handful (the old, the frail and the chronically ill) develop life threatening symptoms mainly due to blood clotting. The disease kills people in direct proportion to natural mortality but at an increased rate.
This is not a typical respiratory disease. It makes sense to see it as the product of something synthesised in a lab which has no strong parallel in nature.
All the vaccines which have been developed to prevent covid-19 disease have the common feature that they stimulate your body to produce this spike protein, which gets into the blood, making platelets clump together causing clotting, and accumulating in the brain, spleen, bone marrow, liver, adrenal glands, ovaries, heart and lungs. The common "minor" side effects (headaches, dizziness, fatigue etc) are all symptoms of blood clots.
These "side-effects" of the vaccines are very similar to the more severe symptoms of covid-19 itself. This is not a coincidence. In both cases the symptoms are a result of the pathogenicity of the spike protein.
It's still true that healthy people have little to fear from the virus, and it's still true that the media has engaged in a grotesque level of fear mongering, and it's still true that the number of deaths from the virus has been exaggerated.
But consider this: what if asymptomatic people were able to pass this "mostly harmless" virus via their breath?
The idea that this was possible evolved out of early epidemiological evidence like the Diamond Princess, where hundreds of elderly people became ill and quite a few died, despite being locked inside their cabins. These people were never exposed to symptomatic disease carriers.
It was because of this early data that social distancing and lockdowns came to be seen as "thinkable" in Western democractic countries which place a premium on indivdual rights.
When you think about it, if this was made in a lab, it was the perfect way to undermine the values of liberal democracy, to make the West "more like China".
If we see this as a Chinese plot, then it was also a brilliant way for China to outstrip the West economically. The Chinese would presumably have understood how the virus works, and would have decided to wear the consequences of having a larger than normal die-off of the elderly and sick within their population. We need to recognise that within the framewok of communist, collectivist ideology, the individual has much less "cachet", and unproductive individuals in particular are not of great importance. Thus, losing a proportion of these economically useless members of society would not necessarily phase the communist leadership a great deal.
In the West, on the other hand, this same pattern of mortality would trigger mass panic. The Chinese would have known this, and would have anticipated that Western nations would wreck their economies in a futile attempt to protect their risk-averse, aging populations.
If any of this is true then you have to hand it to the Chinese - they are absolutely brilliant and have outplayed us to perfection.
(SATIRE)
This is an overtly political article which reveals the intent of powerful forces in New Zealand to force vaccinate people and to persecute anyone who stands in the way of their genocidal plans. They don't give a rat's arse about science. They have clearly stated that they are going after doctors and scientists. A full purge is imminent.
Get out while you still can. They will probably close the borders soon.
(SATIRE)
Geoff, my advice is, get out of New Zealand before it's too late. It is a false paradise, soon to be a killing field. Pay whatever it takes. Go to Mexico. I'll meet you there.
My first question is:
Have there been any viruses which have arisen from nature? I ask this because the way I see it, viruses arise when the health of the human is inadequate. Take for example influenza. Regardless of if you get the flu jab or not, most people don't get the flu anyway. Most people will come down with a cold once or twice a year but not the flu. A virus has been described as our bodies janitors, which come out to clean away the mess when the standard self-regulatory cleaning mechanisms are unable to cope. I.e. we remove waste naturally through urine, feces, sweat and exhalation, possibly in dead skin cells, hair and nails as well. When we accumulate additional toxins, our body eliminates them also through the mucous pathways resulting in watery eyes, sneezing/snot and coughing. Temporarily strain may be placed on the kidneys, liver, etc to accommodate and potentially on the skin in the form of eczema, etc. But when the body is in a dire health state and cannot cope with these normal waste disposal mechanisms due to an overload of toxins, the janitor (virus) comes out and cleans up. But he doesn't clean up gently. He knows the house needs cleaning quickly with some elbow grease. He (the virus) literally scours and hoses down and roughens up the whole place (any wonder you get a headache and low energy when you "have a virus". And he lets you know he's there because he turns the furnace on to burn the excess waste since there is no room left for landfill (high fever).
So then... how can it be we've had The Spanish Flu and the Swine Flu and the Bird Flu and the Covid Flu? Isn't it the same janitor every time?
Well, I don't know how to best elaborate this and could use some better examples if anyone can contribute.
For now, let's say you have a grain or wheat and a grain of rye. You put both grains in the same controlled soil, under the same daylight and temperature conditions and you give both grains the same controlled amounts of water. What's the result? Two entire different plants, right!? The point is, at one part of the equation, it's the initial seed which drives the process/outcome.
So what is the seed of the semi-spread (because it's not wide spread, never has been) similar viral loads people are experiencing? At one point in history, we were using Tin in our canned products, something nearly everybody was using. There's information suggesting this is what led to Polio. At one point we used lead in our paint. Once again, exposure to most people at the same time. EMF/R 100% causes damage to human biology. It is irrefutable. So we cannot rule out 3G, 4G, 5G as new toxins shared by masses of people. Genetically modified foods. Chemtrails (of which the ingredients could change from generation to generation). New artificial preservative, sweeteners, colours - all of which are directly ingested toxins. Take Coke Zero for example or whatever it is called now. How many hundreds of millions around the world consume the toxin put in this drink on a regular basis?
Is it possible that viruses are shared/contracted? I'm not sure. I'm very skeptical of germ theory and very much (but not 100%) in favour of terrain theory. Could bacteria be shared? Absolutely, I'm open to this idea. And excess bacteria is prevalent when individuals have dis-ease symptoms. Bear in mind, bacteria can also contain viruses. So could Covid be spread from person to person? Possibly. I don't want to rule it out. If it's possible to genetically engineer a bacteria or a virus in a laboratory to make it spread more or make it more deadly, then yes, this grants greater possibility of spread-ability. Although, I don't know that I can yet agree that 'the virus' is spreading. A genetically engineered virus that makes it "gain function" (since viruses are not alive and therefore do nothing such as seek out hosts to infect) should no longer be called a virus IMO. Imagine taking some metal, melting it down and re-shaping it into a pure metal axe. Would you still call it a bit of metal? Of course not. It has "gained function".
I know that's a little off topic. Other than this I can say I agree with Able about the elites wanting to control/rule and reduce population. They are attempting this by multiple means. This is just one method. The only way I see out of it is for people to learn responsibility in becoming individuals, not reliant on corporations or governments, understanding the extent that their personal liberties extend to and then, only after they understand this, sharing and co-operating with each other on a community level, as opposed to a global level. Globalism is a major cause of wealth and liberty theft. Do we need to go to war with China if indeed they engineered the virus? No. We never need to invade other countries. We certainly need to defend ourselves, so military resources are an important thing to keep and upgrade but not for the purpose of attack, only for the purpose of attack. The way to fight back against China is to cease trading. The way to cease trading is to produce more locally. The way to do that is to remove government local red tape and introduce more government international trade red tape.
Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease
LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself.
The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19’s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies.
“A lot of people think of it as a respiratory disease, but it’s really a vascular disease,” says Assistant Research Professor Uri Manor, who is co-senior author of the study. “That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.”
Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others.
While the findings themselves aren’t entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. There’s been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented.
In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model—proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.
The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.
Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own.
“If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,” Manor explains. “Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.”
The researchers next hope to take a closer look at the mechanism by which the disrupted ACE2 protein damages mitochondria and causes them to change shape.
Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong University in Xi’an, China; Cara R. Schiavon, Leonardo Andrade, and Gerald S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark Hepokoski, Jason X.-J. Yuan, Atul Malhotra, Jin Zhang of the University of California San Diego; Lili Chen, Qian Yin, Ting Lei, Hongliang Wang and Shengpeng Wang of Xi’an Jiatong University Health Science Center in Xi’an, China.
The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xi’an Jiaotong University; and Xi’an Jiaotong University.
The novel coronavirus’ spike protein plays additional key role in illness - Salk Institute for Biological Studies
LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key r…
Salk Institute for Biological StudiesSARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells. Vascular endothelium can be infected by SARS-CoV-2,1 which triggers mitochondrial reactive oxygen species production and glycolytic shift.2 Paradoxically, ACE2 is protective in the cardiovascular system, and SARS-CoV-1 S protein promotes lung injury by decreasing the level of ACE2 in the infected lungs.3 In the current study, we show that S protein alone can damage vascular endothelial cells (ECs) by downregulating ACE2 and consequently inhibiting mitochondrial function.
We administered a pseudovirus expressing S protein (Pseu-Spike) to Syrian hamsters intratracheally. Lung damage was apparent in animals receiving Pseu-Spike, revealed by thickening of the alveolar septa and increased infiltration of mononuclear cells (Figure [A]). AMPK (AMP-activated protein kinase) phosphorylates ACE2 Ser-680, MDM2 (murine double minute 2) ubiquitinates ACE2 Lys-788, and crosstalk between AMPK and MDM2 determines the ACE2 level.4 In the damaged lungs, levels of pAMPK (phospho-AMPK), pACE2 (phospho-ACE2), and ACE2 decreased but those of MDM2 increased (Figure [B], i). Furthermore, complementary increased and decreased phosphorylation of eNOS (endothelial NO synthase) Thr-494 and Ser-1176 indicated impaired eNOS activity. These changes of pACE2, ACE2, MDM2 expression, and AMPK activity in endothelium were recapitulated by in vitro experiments using pulmonary arterial ECs infected with Pseu-Spike which was rescued by treatment with N-acetyl-L-cysteine, a reactive oxygen species inhibitor
Link
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The chinese seemed more than happy to help in its creation.. but all needles (pun intended) point to it being 80% complete already when it was gifted to them. It even come with fauci's lead gain of function scientists who would have made sure they put the need pieces into the right place. While the Chinese are easily made into the evil plotters... its borderline criminal to not mention that it was already being worked on by fauci's team, that hundreds of his peers had demanded he stop his work and that it was all packed up and sent to wuhan where it was funded through a web of sub grants. It now emerges that fauci was worried from day one that this was his baby and put his main men on red alert. the Mrna vaccines we know were a collaboration between fauci's moderna and DARPA and god knows whats really in the non Mrna vaccines because we know the 13 year history of trying to make a typical vaccine for SARS..... (a lot of dead ferrets). Im no friend of communist run china (I have nothing against regular chinese people) But we know who was cooking this up before it went there... was it always the plan to release it and blame them? Did it just get out due to sloppy security? If it was meant for later then china would have known that it was the biological they did the home stretch on and would have brought it up.. so perhaps it was the perfect move to "let" it leak from china.... I have heard several times that china closed all ways out of wuhan and yet made sure the international airport was fully functional... was this to intentionally infect other people and was that to cover up china's involvement or part of the plan?
Other questions i have.... Was it supposed to be stronger or just to be used as a marker to bring in the system the msm and governments seem so invested in? Why are globalist think tanks being so open and virtually saying that perhaps we needed it to happen to bring in a more sustainable future? Why have so many western countries praise china's communist/social credit system? Why am i getting the feeling that this credit system is what 1984 was warning us about? In my mind the PTB were to quick to pounce and their drills were to spot on and to close to be dismissed by even a skeptic that has had more than just a snooty look at other peoples links.... And i have read agenda 2030 right out in the open in the last four months more times than i read it in forums the previous decade... Its almost like its acceptable to mention it all of a sudden... Like non of these things were ever laughed at as conspiracy theories... I think that even a end of life leaper could smell which way the PTB want this world to go..
I lean more to the view that Fauci was being used by an oligarchy whose goal was to depose the US as the leading power in the world and grant that title to China.
So it wasn't a strictly Chinese plot, but the effect was to hand power to China, exploiting the weaknesses of Western culture in a hybrid war which leads to the collapse of liberal democracy and it's replacement with the technocractic oligarchical collectivism.
It is very interesting that china is run like a sweatshop. Its people little more than cattle for industry. Its airshed a toxic soup and its people as disposable as most of the products they produce in their sad and sequestered lives. Top western countries more than happy to look the other way and also single out china "from" the 2030 agenda to close down industry through the incoming environmental decimation of western industry. My question is.. Is china the author of what seems like a massive win economically? Or is it being enslaved forever with its people serving as cancer ridden cogs in some secret agreement that its ruling class is more than happy to sign it up too for profit? My instincts tell me that the so called elites have had enough and they want the world they own three times over on paper through their central bank scam. I get pulled this way and that and spend time in different rabbit holes.... but the truth is that its always been a war between the moneyed and the serfs. the last 100 years they tried a few things different and there was less rebellion.. But economically this system is doomed. The moneyed are not stupid and they know how to work a calculator. They preach renewables because its the only reasonable sounding argument they have that doesn't include the word cull. The earths bounty is finite... without the advancement in energy production then these descendants of homicidal maniacs, thieves and con artists know that the jig is up. while they are happy to make war, they know that it always comes with risk (to themselves and their holdings, they don't give a shit about us). So we know that they want to start a new game, we know that they want most of us dead, we know that they want to take back the freedom we thought was god given... everything IMHO, points to covid being the beginning point of reining in these freedoms we though were certainties. All these countries coming up with the same ideas (movement monitoring, passports, color of underpants) all at the same time.. like it was their idea... I spent half the time of the last year swallowing vomit it was that obvious. But i ask you this.. does it matter is it was leaked or was planned to be leaked in three months after that anyway? The plans were all set in motion, the ideas had all been discussed and hammered out, the agreements made... we know one crucial part.. the grand plan.. So we know that these attacks will not be random and we know what will be attacked. Food (mostly meat), oil, coal, electricity, hospitals, business and transport. They will throw in a few red herrings... but there is an agenda and its anti human.... Any bloody way. i have waffled on to much, i await other people perspectives.